Medical Biochemistry 2 has been designed to develop students' knowledge acquired in Medical Biochemistry 1 in the area of human metabolism through the key catabolic and anabolic metabolic pathways. Students will gain insight into the principles of bioenergetics and regulatory aspects of integrated metabolism. Students will also apply their knowledge in a technology-enhanced learning environment as well as small group case studies to examine how metabolism changes in the transition from healthy to diseased states and the body's response to exercise and trauma. Students will enhance their practical and in modern biochemical techniques (chromatography, spectrophotometric kit assays). Students will work in small groups using higher order critical thinking skills to solve case studies.
|Academic unit:||Faculty of Health Sciences and Medicine|
|Subject title:||Medical Biochemistry 2|
Delivery & attendance
|Attendance and learning activities:||Attendance is compulsory for tutorials/PBLs and laboratories. We strongly recommend lecture attendance because successful student performance is generally correlated with attendance and engagement with the subject. Group activities and assessment are reliant on student numbers and may be altered as necessary.|
|Prescribed resources:|| |
|[email protected] & Email:||[email protected] is the online learning environment at Bond University and is used to provide access to subject materials, lecture recordings and detailed subject information regarding the subject curriculum, assessment and timing. Both iLearn and the Student Email facility are used to provide important subject notifications. Additionally, official correspondence from the University will be forwarded to students’ Bond email account and must be monitored by the student.|
To access these services, log on to the Student Portal from the Bond University website as www.bond.edu.au
This subject is not available as a general elective. To be eligible for enrolment, the subject must be specified in the students’ program structure.
Assurance of learning
Assurance of Learning means that universities take responsibility for creating, monitoring and updating curriculum, teaching and assessment so that students graduate with the knowledge, skills and attributes they need for employability and/or further study.
At Bond University, we carefully develop subject and program outcomes to ensure that student learning in each subject contributes to the whole student experience. Students are encouraged to carefully read and consider subject and program outcomes as combined elements.
Program Learning Outcomes (PLOs)
Program Learning Outcomes provide a broad and measurable set of standards that incorporate a range of knowledge and skills that will be achieved on completion of the program. If you are undertaking this subject as part of a degree program, you should refer to the relevant degree program outcomes and graduate attributes as they relate to this subject.
Subject Learning Outcomes (SLOs)
On successful completion of this subject the learner will be able to:
- Demonstrate a sound knowledge and understanding of the key metabolic pathways relating to carbohydrate, lipid and nitrogen metabolism in health and disease.
- Describe and explain in detail how the metabolic pathways are regulated and how these pathways integrate into other metabolic pathways to maintain the organism as a whole
- Understand the consequences of metabolic disturbances in terms of patient symptoms in a number of key disease states.
- Locate information relating to various biochemical topics and interpret appropriate data.
- Present and interpret scientific data that is conducted from experiments
- Develop teamwork and leadership skills in a small group environment
- Demonstrate competencies in advanced biochemical techniques using higher order analytical skills to solve case studies in a problem-based learning environment
|Problem-based Learning||ilearn Student activities in small groups during the tutorials/PBLs. Students obtain feedback on their participation providing an opportunity for improvement.||20%||Ongoing||1, 2, 3, 4, 5, 6, 7.|
|Online Quiz||2 x 10% in ilearn test - weeks 4 and 9||20%||Ongoing||1, 2, 3.|
|Laboratory Activity||Weeks 2, 4, 6 and 8||25%||Progressive||5, 6, 7.|
|Written Report||A group assignment on metabolic pathway based theme||15%||Week 11||1, 2, 3, 4, 5, 6.|
|Online Quiz||ilearn MCQ/SAQ - final||20%||Week 13||1, 2, 3, 4, 5, 6.|
- * Assessment timing is indicative of the week that the assessment is due or begins (where conducted over multiple weeks), and is based on the standard University academic calendar
- C = Students must reach a level of competency to successfully complete this assessment.
|High Distinction||85-100||Outstanding or exemplary performance in the following areas: interpretative ability; intellectual initiative in response to questions; mastery of the skills required by the subject, general levels of knowledge and analytic ability or clear thinking.|
|Distinction||75-84||Usually awarded to students whose performance goes well beyond the minimum requirements set for tasks required in assessment, and who perform well in most of the above areas.|
|Credit||65-74||Usually awarded to students whose performance is considered to go beyond the minimum requirements for work set for assessment. Assessable work is typically characterised by a strong performance in some of the capacities listed above.|
|Pass||50-64||Usually awarded to students whose performance meets the requirements set for work provided for assessment.|
|Fail||0-49||Usually awarded to students whose performance is not considered to meet the minimum requirements set for particular tasks. The fail grade may be a result of insufficient preparation, of inattention to assignment guidelines or lack of academic ability. A frequent cause of failure is lack of attention to subject or assignment guidelines.|
For the purposes of quality assurance, Bond University conducts an evaluation process to measure and document student assessment as evidence of the extent to which program and subject learning outcomes are achieved. Some examples of student work will be retained for potential research and quality auditing purposes only. Any student work used will be treated confidentially and no student grades will be affected.
Students must check the [email protected] subject site for detailed assessment information and submission procedures.
Policy on late submission and extensions
A late penalty will be applied to all overdue assessment tasks unless an extension is granted by the subject coordinator. The standard penalty will be 10% of marks awarded to that assessment per day late with no assessment to be accepted seven days after the due date. Where a student is granted an extension, the penalty of 10% per day late starts from the new due date.
Policy on plagiarism
University’s Academic Integrity Policy defines plagiarism as the act of misrepresenting as one’s own original work: another’s ideas, interpretations, words, or creative works; and/or one’s own previous ideas, interpretations, words, or creative work without acknowledging that it was used previously (i.e., self-plagiarism). The University considers the act of plagiarising to be a breach of the Student Conduct Code and, therefore, subject to the Discipline Regulations which provide for a range of penalties including the reduction of marks or grades, fines and suspension from the University.
Feedback on assessment
Feedback on assessment will be provided to students within two weeks of the assessment submission due date, as per the Assessment Policy.
If you have a disability, illness, injury or health condition that impacts your capacity to complete studies, exams or assessment tasks, it is important you let us know your special requirements, early in the semester. Students will need to make an application for support and submit it with recent, comprehensive documentation at an appointment with a Disability Officer. Students with a disability are encouraged to contact the Disability Office at the earliest possible time, to meet staff and learn about the services available to meet your specific needs. Please note that late notification or failure to disclose your disability can be to your disadvantage as the University cannot guarantee support under such circumstances.
During the 1st week we provide an overview of metabolism using a state of the art lightboard video presentation which sets the scene for a more detailed treatment of the various pathways for carbohydrates, proteins, lipids.and nitrogen metabolism. Importantly we provide a sound introduction to bioenergetics which helps us understand the flow of energy through the pathways.1, 2, 3, 4.
In this Topic we cover, in detail, glycolysis, gluconeogenesis, glycogen breakdown and synthesis, pentose phosphate pathway as well as some systemic pathways such as Cori Cycle. Anaerobic and aerobic respiration will be dealt with. There is an emphasis on understanding biochemical redox reactions and the role of the redox cofactors. Throughout the course we focus on molecular level understanding of the pathways/enzyme function and regulation as well as the impact of systemic hormonal regulation. Students should strive to understand the role and key site of regulation in each pathway.1, 2, 3, 4, 5, 7.
In this Topic we examine the TCA Cycle as the hub of intermediary metabolism. Under aerobic conditions this Cycle will be most active and facilitate production of ATP via oxidative phosphorylation. Students should be able to draw the Cycle and components of the ETC; identify how these systems are regulated and explain oxidative phosphorylation and the chemiosmotic theory. Medical scenarios and pathologies will be mentioned where relevant.1, 2, 3, 4.
Here we delve into the details of beta-oxidation of fatty acids and fatty acid synthesis. Students should highlight how these processes are regulated and link the overall chemical logic to other pathways examined in the course. We also cover how lipids are transported & stored through the body and hormonal regulation thereof. Medical applications, relevant pathologies and biochemical basis of their treatment is provided.1, 2, 3, 4, 5, 6, 7.
This broad topic covers amino acid metabolism (link to TCA Cycle), purine and pyrimidine metabolism. Since we cover a number of pathways in this topic for which the key focus should be on the overall role of each pathway, key points of regulation and mechanisms of regulation, key enzymes & intermediates. Sites of action & mechanism of relevant pharmaceutical inteventions should be noted.1, 2, 3, 4, 5, 6.
At this stage we take a broad systemic view of metabolism in terms of the fed, fasted and starvation states examining which pathways will be active or inhibited and the mechanisms by which that occurs through hormonal regulation (& subsequent covalent or allosteric modification). It is important to identify the key sites of regulation in the main pathways and provide examples of reciprocal regulation.1, 2, 3, 4, 5, 6.