Prof Russ Chess-Williams

Prof Russ Chess-Williams

Position:
  • Professor of Pharmacology
    Faculty of Health Sciences and Medicine
Location:
Level 4, 5. Faculty of Health Sciences and Medicine, Bond University

Professional biography

(2011-2012) Associate Dean of Research, Faculty of Health Sciences & Medicine, Bond University.

(2007-2011) Head of Biomedical Science Department, Bond University, Australia.

(1990-2006)- Lecturer/Senior Lecturer, Department of Biomedical Science, University of Sheffield, UK

(1989-90) - Squibb Senior Research Fellow, Department of Pharmacology & Therapeutics, University of Liverpool, UK

(1985-1989) - Bristol-Myers Lecturer in Cardiovascular Pharmacology, Department of Pharmacology & Therapeutics, University of Liverpool, UK
(1983-1985) - Post-doctoral Research Fellow, Departments of Cardiology, Welsh National School of Medicine, and Pharmacology, Welsh School of Pharmacy, Cardiff, UK

Statement of research interests

Laboratory studies to enhance our knowledge of the lower urinary tract, with the aim of developing new treatments, or enhancing current treatments of the following conditions:

Overactive bladder
Cancers of the lower urinary tract
Stress incontinence
Ureteral stones
Benign prostatic hyperplasia
Erectile dysfunction

Statement for HDR students

The research group specialises in studies of the lower urinary tract using isolated tissues to examine contraction, biochemical assays to measure release of ATP, acetylcholine and prostaglandins, histological techniques to examine structure and protein distribution, molecular biology techniques to measure proteins and radioligand binding to measure receptor densities and characteristics.

Current projects examine the receptors and ion channels of the bladder, urethra, ureter, prostate and cavernosum to identify new targets for drugs to treat overactive bladder, stress incontinence, renal stones, and enlarged prostate and erectile dysfunction.

Recent studies also include the effects of cytotoxic drugs and metabolites on bladder function to identify the causes of side effects, interactions between anti-cancer drugs, and treatments to enhance the effects of radiotherapy and other cytotoxic drugs.

Higher degree research student projects

  • Analytical and Pharmacological investigation into stimulatory and psychoactive substances in Performance Enhancing Supplements and emerging drugs of abuse
  • Contractile Activity of the Bladder Urothelium and Lamina Propria
  • Cyclophosphamide and ifosfamide: Mechanisms of cytotoxic action and consequences for normal bladder function
  • Cytotoxic drugs and their effects on bladder function
  • Drug targets for urinary and faecal incontinence and anal fissures
  • Effects of hypoxia on prostate cancer cell physiology and pharmacology
  • Intravesical gemcitabine treatment: Repercussions on normal bladder function
  • Intravesical gemcitabine treatment: Repercussions on normal bladder function
  • Mechanisms controlling ureteral motility
  • Non-neuronal ATP: Regulation of release and action in the bladder
  • Quinazoline-based Alpha 1 - Adrenoceptor antagonists and prostate cancer
  • Regulation of mediator release from the bladder urothelium
  • The role of the inflammatory mediators histamine and prostaglandin in modulating bladder contractile activity

Areas of research expertise

  • Clinical Sciences
  • Pharmacology and Pharmaceutical Sciences